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spatial transcriptomics samples ots mock  (Spatial Transcriptomics Inc)
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Spatial Transcriptomics Inc spatial transcriptomics samples ots mock
Short term experimental setup: Age-matched K18-hACE2 mice vaccinated with Spikevax mRNA-vaccine (intramuscularly) or <t>OTS-206</t> (intranasally) (n=8 mice/group). Challenge with SARS-CoV-2 Delta VOC, lung harvest at 2- (n=4) or 5-days (n=4) post challenge (dpc). Mock control group was vaccinated with culture medium. Spatial transcriptomics samples (n=11): OTS <t>2dpc</t> – (n=2), OTS 5dpc (n=2), mRNA 2dpc (n=2), mRNA 5dpc (n=3), mRNA mock (n=1), OTS mock (n=1). a , Pearson’s correlation coefficients were calculated between total SARS-CoV-2 gene counts and all host genes to determine spatial correlations. These values are plotted against each other on the x and y axis for the OTS and mRNA 2 dpc samples to show that the spatial gene expression signatures are very similar, as their correlation coefficients are nearly identical. b , Top 20 spatially most correlated genes in the lungs of infected mice vaccinated with OTS-206 or mRNA vaccine. c , Changes in proinflammatory cytokine expression between conditions (n=4/group). d , Spatial JAK-STAT pathway activity in the lung. We can see the co-occurrence between SARS-CoV-2 transcripts from d , and the increased JAK-STAT activity.
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Short term experimental setup: Age-matched K18-hACE2 mice vaccinated with Spikevax mRNA-vaccine (intramuscularly) or OTS-206 (intranasally) (n=8 mice/group). Challenge with SARS-CoV-2 Delta VOC, lung harvest at 2- (n=4) or 5-days (n=4) post challenge (dpc). Mock control group was vaccinated with culture medium. Spatial transcriptomics samples (n=11): OTS 2dpc – (n=2), OTS 5dpc (n=2), mRNA 2dpc (n=2), mRNA 5dpc (n=3), mRNA mock (n=1), OTS mock (n=1). a , Pearson’s correlation coefficients were calculated between total SARS-CoV-2 gene counts and all host genes to determine spatial correlations. These values are plotted against each other on the x and y axis for the OTS and mRNA 2 dpc samples to show that the spatial gene expression signatures are very similar, as their correlation coefficients are nearly identical. b , Top 20 spatially most correlated genes in the lungs of infected mice vaccinated with OTS-206 or mRNA vaccine. c , Changes in proinflammatory cytokine expression between conditions (n=4/group). d , Spatial JAK-STAT pathway activity in the lung. We can see the co-occurrence between SARS-CoV-2 transcripts from d , and the increased JAK-STAT activity.

Journal: Nature Microbiology

Article Title: A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications

doi: 10.1038/s41564-024-01755-1

Figure Lengend Snippet: Short term experimental setup: Age-matched K18-hACE2 mice vaccinated with Spikevax mRNA-vaccine (intramuscularly) or OTS-206 (intranasally) (n=8 mice/group). Challenge with SARS-CoV-2 Delta VOC, lung harvest at 2- (n=4) or 5-days (n=4) post challenge (dpc). Mock control group was vaccinated with culture medium. Spatial transcriptomics samples (n=11): OTS 2dpc – (n=2), OTS 5dpc (n=2), mRNA 2dpc (n=2), mRNA 5dpc (n=3), mRNA mock (n=1), OTS mock (n=1). a , Pearson’s correlation coefficients were calculated between total SARS-CoV-2 gene counts and all host genes to determine spatial correlations. These values are plotted against each other on the x and y axis for the OTS and mRNA 2 dpc samples to show that the spatial gene expression signatures are very similar, as their correlation coefficients are nearly identical. b , Top 20 spatially most correlated genes in the lungs of infected mice vaccinated with OTS-206 or mRNA vaccine. c , Changes in proinflammatory cytokine expression between conditions (n=4/group). d , Spatial JAK-STAT pathway activity in the lung. We can see the co-occurrence between SARS-CoV-2 transcripts from d , and the increased JAK-STAT activity.

Article Snippet: Spatial transcriptomics samples (n=11): OTS 2dpc – (n=2), OTS 5dpc (n=2), mRNA 2dpc (n=2), mRNA 5dpc (n=3), mRNA mock (n=1), OTS mock (n=1). a , Pearson’s correlation coefficients were calculated between total SARS-CoV-2 gene counts and all host genes to determine spatial correlations.

Techniques: Control, Gene Expression, Infection, Expressing, Activity Assay